A targeted delivery strategy for the development of potent trypanocides

TitleA targeted delivery strategy for the development of potent trypanocides
Publication TypeJournal Article
Year of Publication2017
AuthorsGordhan, H.M., Milanes J.E., Qiu Y., Golden J.E., Christensen K.A., Morris J. C., and Whitehead, D.C.
JournalChemical Communications
Date Published07/2017
Abstract

A new drug delivery strategy was investigated for the development of potent anti-parasitic compounds against Trypanosoma brucei, the causative agent of African sleeping sickness. Thus, potent in vitro hexokinase inhibitors were rendered cytotoxic by appending a tripeptide peroxosomal targeting sequence that facilitated delivery of the molecular cargo to the appropriate organelle in the parasite.

URLhttps://pubs.rsc.org/en/content/articlelanding/2017/CC/C7CC03378H#!divAbstract
DOI10.1039/C7CC03378H