|Title||A targeted delivery strategy for the development of potent trypanocides|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Gordhan, H.M., Milanes J.E., Qiu Y., Golden J.E., Christensen K.A., Morris J. C., and Whitehead, D.C.|
A new drug delivery strategy was investigated for the development of potent anti-parasitic compounds against Trypanosoma brucei, the causative agent of African sleeping sickness. Thus, potent in vitro hexokinase inhibitors were rendered cytotoxic by appending a tripeptide peroxosomal targeting sequence that facilitated delivery of the molecular cargo to the appropriate organelle in the parasite.